Hepatitis B Virus

Contents

• Overview
• Transmission
• Pathogenesis
• Characteristics of Infection
• Risks & Prevention
• Treatment
• Natural Medicines
• FDA-Approved Medication
  • Overview
  • Chemical Data
  • Mechanism of Action
  • Physiological Effect
• References

Chemical Data: The chemical name for entecavir is 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one. Its molecular formula is C₁₂H₁₅N₅O₃, which corresponds to a molecular weight of 277.12 g/mol (Figure 5). At room temperature, entecavir is a white to off-white powder. It is slightly soluble in water (2.4 mg/mL), and the pH of the saturated solution in water is 7.9 at 25°C ± 0.5°C. Entecavir is administered orally in tablet form. It is available in strengths of 0.5 mg and 1 mg.

Figure 5. Structural formula of entecavir.